Structural Molecular Biology

Illuminating Biological Structures at the Atomic and Molecular Levels

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Macromolecular Crystallography


The SMB macromolecular crystallography (MC) program is a major experimental driver for structural biology research, serving the needs of a large number of academic and biotech groups working in this area, particularly in the Western U.S, developing, providing and supporting cutting-edge technologies for a wide-range of user applications.

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Small Angle X-ray Scattering


X-ray scattering from partially ordered arrays of biomolecules typically provides low-resolution (≥ 7-10 Å) structural information under biologically relevant conditions. Studies are relatively fast, require small quantities of material and are well-suited for time resolved measurements. Applications range from conformational change to folding intermediate studies.

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X-ray Spectroscopy & Imaging


Metal ions have key roles in biological structure and function - from being active sites of many enzymes to having roles in signaling pathways and being key elements of cancer chemotherapies and disease-related biological malfunctions. Synchrotron x-ray spectroscopies are a key tool in determining the geometric and electronic structure of metal centers.

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Upcoming Events

September 8-10, 2020 (Virtual) EXAFS 2020

Sep. 28 - Oct. 9, 2020 (Virtual) 2020 SSRL/LCLS Users' Meeting

New Multi-Technique Proposals (Pilot)

A new Multi-Technique Proposal mechanism has been created for projects that require the use of two or more scientific techniques available at SSRL (both x-ray and electron based). The pilot proposal mechanism will initially cover Small Angle X-ray Scattering, Macromolecular Crystallography and Cryo-Electron Microscopy. A goal is to expand the mechanism in its permanent phase to include additional techniques available at LCLS and spectroscopy and imaging methods at SSRL.

The new pilot proposals will require a thorough justification for the requirement of using two or more techniques. The proposals will be reviewed by an ad hoc Proposal Review Panel comprised of members from the SSRL SMB and Cryo-EM PRPs. The new proposal template is now available and the first deadline for submission will be July 1.

To get started:  Log into User Portal  -> Select SSRL as the Facility -> Choose Submit Structural Biology-related Multi-Technique Proposal from SSRL Proposals pulldown menu.

New Proposals & Extension Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 May 1 April 1
Quarter 2 August 1 July 1
Quarter 3 November 1 December 1

Beam Time Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 August 1 Augut 29
Quarter 2 November 1 January 14
Quarter 3 February 1 April 18