Structural Molecular Biology

Illuminating Biological Structures at the Atomic and Molecular Levels

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Macromolecular Crystallography


The SMB macromolecular crystallography (MC) program is a major experimental driver for structural biology research, serving the needs of a large number of academic and biotech groups working in this area, particularly in the Western U.S, developing, providing and supporting cutting-edge technologies for a wide-range of user applications.

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Small Angle X-ray Scattering


X-ray scattering from partially ordered arrays of biomolecules typically provides low-resolution (≥ 7-10 Å) structural information under biologically relevant conditions. Studies are relatively fast, require small quantities of material and are well-suited for time resolved measurements. Applications range from conformational change to folding intermediate studies.

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X-ray Spectroscopy & Imaging


Metal ions have key roles in biological structure and function - from being active sites of many enzymes to having roles in signaling pathways and being key elements of cancer chemotherapies and disease-related biological malfunctions. Synchrotron x-ray spectroscopies are a key tool in determining the geometric and electronic structure of metal centers.

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New Proposals & Extension Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 May 1 April 1
Quarter 2 August 1 July 1
Quarter 3 November 1 December 1

Beam Time Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 August 1 September 1
Quarter 2 November 1 January 20
Quarter 3 February 22 April 18