Structural Molecular Biology

Illuminating Biological Structures at the Atomic and Molecular Levels

NIH
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Training

2022

2021

2020

2019

Time- and Space-Resolved X-ray Absorption Spectroscopy (XAS) at SSRL: Analysis of Large Data Sets

As SSRL transitions from step-scanning XAS to continuous scanning and quick scanning (QEXAFS), time resolution will improve from 10 minutes per spectrum to below 1 second, meaning that the number of spectra that will need to be analyzed will increase dramatically. A similar situation already exists with space-resolved data in X-ray microscopy where thousands and sometimes even millions of spectra need to be processed. With these new parameters, we need appropriate software to process these data batches and extract time- and space-resolved chemical information. This course will present examples of large XAS data sets and solutions for their batch processing, including hands-on exercises. The future in correlated data collection and analysis will also be discussed.

RapiData 2019 at SSRL

Synchrotron radiation is an indispensable tool in macromolecular crystallography and most of the macromolecule structures deposited in the PDB are solved and refined with data collected at synchrotron sources. Some of the skills needed to make optimal use of state-of-the-art beamlines and data processing and analysis software are difficult to learn without intensive hand-on training.

2019 Resonant Inelastic X-ray Scattering with Hard X-rays

This workshop on the fundamental aspects of hard X-ray Resonant Inelastic X-ray Scattering (RIXS) includes lectures and tutorials. Hard X-ray RIXS is a powerful spectroscopic tool due to the two-dimensional data planes, the high resolution in the energy transfer direction and the large penetration depth of the X-rays.

2018

Metals in Structural Biology

A workshop held at the joint SSRL/LCLS Users' Meeting September 25, 2018. This workshop showcased the SMB groups expertise in combining spectroscopic methods (EPR, UV-vis, and X-ray spectroscopy), with macromolecular crystallography.

EXAFS 2018 - SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy

SSRL conducted the 2018 SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy between August 13 and August 16. Due to high demand an extra session of the summer school was added and held between September 10 and September 13. The five-day sessions provided training in XAS and Imaging theory, experimental design, data acquisition strategies and FEFF based EXAFS data analysis useful to both new and experienced users.

EMSL Integration 2018

A tutorial and introductory workshop to the X-ray methods available to general users at the SSRL at SLAC, aimed at providing an overview on SMB methods and techniques was held during the EMSL Users Meeting on August 8, 2018. The tutorial was jointly organized by SSRL SMB and NSLS staff.

RapiData 2018 at SLAC - Data Collection and Structure Solving: A Practical Course in Macromolecular X-Ray Diffraction Measurement

RapiData at SLAC is a practical course in macromolecular X-ray diffraction data collection, data processing and structure solution. In addition to macromolecular crystallography the course also included lectures and tutorials on small angle X-ray scattering methods. The aim of the course, held from April 22-27, is to educate and train young scientists in data collection and processing methods at synchrotron beamlines, using state-of-the-art software and instrumentation.

University of Alabama at Huntsville Collaborative Remote Access Workshop

A workshop on the Remote Access Crystallography and the Small Angle X-ray Scattering programs at SSRL was taking place on March 8. The workshop included lectures, remote access crystallography training using the SSRL facilities and tutorials on fixed target and injector methods for serial crystallography at SSRL and LCLS.

2017

Small Angle X-ray Scattering in Structural Biology: A Hands-On Practical Workshop

This workshop focused on all aspects of the experimental application of state-of-the-art synchrotron-based solution X-ray scattering to biological macromolecules and macromolecular complexes. The workshop was split over four days (November 6, November 20-21 and December 4) included introductory lectures, hands-on data collection and data analysis tutorials.

Advanced X-ray Spectroscopy at SLAC: From Theory to Experimental Concepts

A workshop at the joint SSRL/LCLS Users' Meeting September 29, 2017. The emphasis of this workshop was to enable a wider understanding of the diversity of theoretical approaches available at SLAC and their relevance to cutting-edge experiments at SSRL and LCLS investigating electronic structure and dynamics in different application domains.

New Tools for Macromolecular Structure Determination at Physiological Temperatures

A workshop at the joint SSRL/LCLS Users' Meeting September 27, 2017. The workshop focused on new methods available at SSRL and LCLS for protein crystallography at room temperature.

EXAFS 2017 - SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy

SSRL conducted the 2017 SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy between June 19 and June 23. The five-day session provided training in XAS and Imaging theory, experimental design, data acquisition strategies and FEFF based EXAFS data analysis useful to both new and experienced users.

RapiData 2017 at SLAC - Data Collection and Structure Solving: A Practical Course in Macromolecular X-Ray Diffraction Measurement

RapiData at SLAC is a practical course in macromolecular X-ray diffraction data collection, data processing and structure solution. In addition to macromolecular crystallography the course also included lectures and tutorials on small angle X-ray scattering methods. The aim of the course, held from April 16-21, is to educate and train young scientists in data collection and processing methods at synchrotron beamlines, using state-of-the-art software and instrumentation

2016

12th International Conference on Biology and Synchrotron Radiation (BSR)

The International Biology and Synchrotron Radiation (BSR) meetings are held every three years with the aim of presenting and discussing state of the art applications in relevant research fields. BSR is a unique forum to discuss the novel possibilities of synchrotrons and X-ray lasers and to promote their applications to challenging biological problems.

EXAFS 2016 - SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy

SSRL will conduct the 2016 SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy between July 18 and July 22. The five-day session will provide training in XAS and Imaging theory, experimental design, data acquisition strategies and FEFF based EXAFS data analysis useful to both new and experienced users.

XRS 2016 - 8th SSRL School on Synchrotron X-Ray Scattering Techniques

This school will provide a practical users' guide to planning and conducting scattering measurements at SSRL beam lines, and will cover important techniques including small angle scattering, thin-film scattering, powder diffraction, structure refinement and surface x-ray scattering.

RapiData 2016 at SLAC - Data Collection and Structure Solving: A Practical Course in Macromolecular X-Ray Diffraction Measurement

RapiData 2016 at SLAC is a practical course in macromolecular X-ray diffraction data collection, data processing and structure solution. The aim of the course is to educate and train young scientists in data collection and processing methods at synchrotron beamlines, using state-of-the-art software and instrumentation

2015

2014

2013

2012

Structural Molecular Biology Summer School 2012

The structural molecular biology (SMB) summer school 2012 will be held at SSRL between July 16th-20th and will focus on the following disciplines: Macromolecular Crystallography, Small Angle X-Ray Scattering, X-ray Absorption Spectroscopy, X-ray Fluorescence Imaging and X-ray Emission Spectroscopy. The goal of the summer school is to disseminate information about scientific opportunities in synchrotron techniques applicable to biologically relevant systems and to train the participants at both the beginners and expert level to successfully plan, execute and report their research at SSRL.

2012 SSRL Workshop on XAS and RIXS Data Analysis Using CTM4XAS and CTM4RIXS

A two-day workshop on the fundamental aspects of x-ray spectroscopy, including lectures and tutorials on the use of CTM4XAS and CTM4RIXS will be held on June 28-29th, 2012. The first day will focus on lectures and demonstrations by Prof. de Groot. The second day will be dedicated to advanced data analysis session on participant-driven topics. Participants should indicate in the registration form if they are interested in availing of this option and if they would like to bring specific data sets for discussion on the 29th.

Biological SAXS Symposium - A Tribute to Dr. Hiro Tsuruta

A symposium on biological small angle x-ray scattering is being held at SLAC on February 9, 2012 as a tribute to Dr. Hiro Tsuruta, who for almost 20 years led the development and operation of the Stanford Synchrotron Radiation Lightsource structural biology SAXS (bioSAXS) beam line 4-2 facility. BL4-2 is one of the most highly performing and productive experimental facilities in the world today, and has become a beam line of choice for weakly scattering and challenging biological systems.

2011

2010

2009

Training Archive