SSRL Science Highlights Archive

Approximately 1,700 scientists visit SSRL annually to conduct experiments in broad disciplines including life sciences, materials, environmental science, and accelerator physics. Science highlights featured here and in our monthly newsletter, Headlines, increase the visibility of user science as well as the important contribution of SSRL in facilitating basic and applied scientific research. Many of these scientific highlights have been included in reports to funding agencies and have been picked up by other media. Users are strongly encouraged to contact us when exciting results are about to be published. We can work with users and the SLAC Office of Communication to develop the story and to communicate user research findings to a much broader audience. Visit SSRL Publications for a list of the hundreds of SSRL-related scientific papers published annually. Contact us to add your most recent publications to this collection.

SCIENCE HIGHLIGHT BANNER IMAGES

December 2005
J.K. Yano, M.-H. Hsu, K.J. Griffin, C.D. Stout, E.F. Johnson
Figure 1.

Using x-ray diffraction data collected at SSRL, Scripps researchers Jason Yano, Eric F. Johnson, C. David Stout, and their colleagues have solved the structure of a type of human P450 enzyme called CYP2A6, which is the principal enzyme in the body that degrades nicotine.

Macromolecular Crystallography
BL9-1, BL11-1
November 2005
Figure 1.

When a snowball melts, you can tell it has achieved a liquid state when the frigid water drips through your fingers. But if you could follow the melting process, driven by the heat of your hand, from its very first moments - the first trillionth of second, would you be able to point to the exact moment the snowflake crystals disorder into liquid H2O? That's the challenge facing researchers using the Sub-Picosecond Pulse Source (SPPS) to probe the activities of materials on ultrafast timescales. SPPS makes intense x-ray pulses lasting quadrillionths of a second (femtoseconds), enabling researchers to directly monitor the earliest atomic changes during melting with ultrafast x-ray diffraction.

X-ray diffraction
October 2005
Magnus Sandström, Farideh Jalilehvand, Emiliana Damian, Yvonne Fors, Ulrik Gelius, Mark Jones, Murielle Salomé
Figure 1.

Henry VIII's warship, the Mary Rose, wreaked havoc on the French navy for 34 years until she was wrecked in 1545. Salvaged from the sea in 1982, she now rests in the Mary Rose Museum in Portsmouth, England. Pieces of her helm recently traveled to SSRL and the ESRF in Grenoble, France, where intense x-rays pierced the wood to analyze the sulfur and iron within. Led by University of Stockholm Professor Magnus Sandström, researchers had studied another historical treasure, the Swedish warship Vasa, at SSRL in a similar way in 2001.

BL6-2
October 2005
Uri Raviv, Daniel J. Needleman, Youli Li, Herbert P. Miller, Leslie Wilson, Cyrus R. Safinya
Sketch 1: Lipid Protein

Microtubules, 25 nanometer scale hollow tubules, are critical components in a broad range of functions in eukaryotic cells -- from providing tracks for the transport of cargo to forming the spindle structure for chromosome segregation before cell division. They are used as nanometer scale tracks in neurons for the transport of neurotransmitter precursors and enzymes to synaptic junctions in nerve cell communication.

X-ray scattering
BL4-2
September 2005
Junko Yano, Jan Kern, Klaus-Dieter Irrgang, Matthew J. Latimer, Uwe Bergmann, Pieter Glatzel, Yulia Pushkar, Jacek Biesiadka, Bernhard Loll, Kenneth Sauer, Johannes Messinger, Athina Zouni, Vittal K. Yachandra
Figure 1.

X-rays intended to elucidate the structure of biomolecules may actually damage and alter key parts of the molecules. A research team led by a group from Lawrence Berkeley National Laboratory (in collaboration with researchers from Max-Planck-Institut Mülheim, ESRF, SSRL, and TU Berlin and Freie Universität, Berlin) discovered this while investigating the Mn4Ca complex, a site crucial for splitting water into oxygen during photosynthesis.

X-ray Absorption Spectroscopy
BL9-3, BL10-2
September 2005
Jungwoo Choe, Matthew S. Kelker, Ian A. Wilson
Figure 1.

We have to defend ourselves from the challenge of microbial pathogens every day. Innate immune system represents the first line of defense against microorganisms by selectively detecting foreign molecules. The Toll-like receptors (TLRs) are one of the most important sensors of the innate immune system and recognize conserved molecules from various pathogens including viruses, bacteria, fungi and parasites.

Macromolecular Crystallography
BL11-1
August 2005
John R. Bargar, Samuel M. Webb, Bradley M. Tebo
Figure 1.

Manganese oxides form in the oceanic water column as a result of the bacterially catalyzed oxidation of a relatively abundant form of dissolved manganese. As they settle through the water column, manganese oxides participate in myriad chemical reactions important to sea life and to maintaining the trace-metal composition of sea water. These reactions profoundly impact the geochemical cycling of carbon, nitrogen, sulfur, nutrients and containments.

BL2-1
July 2005
Scott Pegan, Christine Arrabit, Wei Zhou, Witek Kwiatkowski, Anthony Collins, Paul Slesinger, Senyon Choe
Figure 1.

Ion channels in our cells generate the nerve impulses that enable the heart to beat, the body to move, and sensation and thought to occur. Scientists from the Salk Institute for Biological Studies have identified a tiny flexible gateway that controls the rapid-fire opening and closing of a family of ion channels through which nerve-triggering potassium ions flow in and out of cells of the body. Malfunctions in the channels leads to several human diseases, including epilepsy, cardiac arrhythmias and muscle disorders.

Macromolecular Crystallography
BL9-2
July 2005
Tomohisa Kuzuyama, Joseph P. Noel, Stéphane B. Richard
Red

Using x-ray diffraction data collected on Beam Line 9-2 at SSRL, and other beam lines at the ESRF and BNL, scientists at The Salk Institute for Biological Studies discovered the three-dimensional structure of a protein that bacteria use to make biologically active compounds. By effectively engineering this protein, scientists may be able to create new drugs with therapeutic properties.

Macromolecular Crystallography
BL9-2
June 2005
Christopher S. Kim, James J. Rytuba, Gordon E. Brown, Jr.
Figure 1.

Mercury (Hg) is a naturally occurring element that poses considerable health risks to humans, with high exposure levels resulting in damage to the brain, heart, kidneys, lungs, and immune system. Young children and unborn babies are particularly vulnerable to mercury, which can affect their nervous systems and impair their neurological development. As a result, mercury is one of the most strictly regulated pollutants by the Environmental Protection Agency (EPA), which controls mercury emissions from coal-fired power plants and issues consumption advisory warnings for various types of fish, the primary route of mercury exposure to humans

BL4-3, BL11-2

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