Approximately 1,700 scientists visit SSRL annually to conduct experiments in broad disciplines including life sciences, materials, environmental science, and accelerator physics. Science highlights featured here and in our monthly newsletter, Headlines, increase the visibility of user science as well as the important contribution of SSRL in facilitating basic and applied scientific research. Many of these scientific highlights have been included in reports to funding agencies and have been picked up by other media. Users are strongly encouraged to contact us when exciting results are about to be published. We can work with users and the SLAC Office of Communication to develop the story and to communicate user research findings to a much broader audience.
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Patient-derived Antibodies Achieve 100% Protection against Mpox
Mpox emerged as a serious global health threat in 2022, spreading rapidly between people in ways not seen before. The virus has developed concerning mutations that may make it more contagious and harder to treat with existing vaccines and drugs.
In-device Battery Failure Analysis
Lithium-ion batteries power our modern electronics, from smartphones to wireless earbuds, but their lifespan remains a challenge, especially under real-world conditions.
Spectroscopic Signature of Electronic Pairing in the Normal State of Cuprate Superconductors
Superconductors typically work only at extremely cold temperature – close to absolute zero. Researchers from Stanford University, SSRL and SIMES have been looking for superconductor materials that can perform at higher temperatures.
Structural Intermediate of Transglutaminase 2 in Complex with Two Calcium Ions Sheds Light on New Treatments for Celiac Disease
Celiac disease is an autoimmune disorder where the body's immune system attacks its own tissues when gluten is consumed. At the heart of this reaction is an enzyme called Transglutaminase 2 (TG2). TG2 helps modify gluten proteins in a way that makes them more likely to trigger this harmful immune response.
Pinning the Geometrically-frustrated Flat Band to the Fermi Level with Electron Correlation
Topological flat bands in quantum materials represent a fascinating subject in condensed matter physics, often associated with numerous exotic phenomena, including superconductivity, magnetism, and charge density wave order. Flat bands are commonly found in quantum materials where the Coulomb interactions are comparable or larger than the electron kinetic energy.
Unique Novel Drug Shows Promise Against SARS-CoV-2
Olgotrelvir (STI-1558) is a novel antiviral drug designed to address the challenges posed by the emergence of new, more infectious and virulent SARS-CoV-2 variants. This drug is particularly important for populations at risk who may not benefit from existing treatments like Paxlovid due to potential drug-drug interactions.
Nanoscale Chemical Imaging with Structured X-ray Illumination
High-resolution x-ray imaging can reveal chemical details in a number of fields including detection of metal contaminations in Si wafers; electrode dissolution and precipitation in lithium-ion batteries; and metal poisoning in catalytic materials for petroleum refinery – among others.
Visualizing the Mechanism of an Ancient Pathway in the Carbon Cycle
In the early days when life was just beginning to dawn on planet earth, the first organisms were faced with a task that all life on earth still faces today: How can I generate energy and grow?
Crystallography Confirms De Novo Protein Binding Modes and Hotspots
Designing customized proteins that have particular biological functions is of great interest to scientists working to develop disease therapies and diagnostics. While the functionality of proteins often involves physical shapes fitting together, the chemical qualities of the molecular surfaces make engineering these interactions complicated.
Structural Evidence that Rodents Facilitated the Evolution of the SARS-CoV-2 Omicron Variant
The pandemic caused by the COVID-19 virus has been complicated by many viral variants. These variants arise from mutations in the virus that bestow new abilities, such as higher infection rates, greater immune system evasion, or increased viral shedding. The omicron variant of the virus suddenly showed up with multiple mutations in its spike protein.
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We can work with users and the SLAC Office of Communication to develop the story and to communicate user research findings to a much broader audience.