Macromolecular Crystallography

Macromolecular Crystallography

The macromolecular crystallography (MC) program is a major experimental driver for structural biology research, serving the needs of a large number of academic and biotech groups working in this area, particularly in the Western U.S. Innovations in synchrotron-based crystallography have been catalyzed by challenges in this field, in particular the growing number of "non expert" user groups and the development and application of new approaches to handle challenging and demanding classes of problems. Solving the phase problem using multi-wavelength anomalous dispersion phasing (MAD) for increasingly large proteins, improving the resolution of large structures with high throughput screening coupled to high quality monochromatic data collection, studying the most challenging biomolecular problems (larger macromolecular complexes with large unit cells, smaller "micro" crystals, and more mechanically and radiation sensitive samples), acquisition and automated approaches to "pipelining" structure determination – all continue to strongly drive the strategy for future developments and in turn give rise to increased user demand and scientific productivity.

• Support
• Instrumentation
• Software
• Research