Biology Department, Brookhaven National Laboratory
It has been proposed that hard X-Ray Free Electron Lasers, such as the Linac Coherent Light Source, may be useful for structure determination of membrane proteins in 2-D crystals [1,2]. More recently, several proposals to develop Energy Recovery Linacs have emerged. Both types of future X-Ray sources are expected to provide hard X-Ray pulses that are ultrashort (about 100 or 200 fs in pulse length) and ultrabright (orders of magnitude brighter than current sources); these characteristics are essential for high-resolution structure determination of protein monolayer samples. Aims, techniques, hurdles, and other relevant issues will be addressed.
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