BioSAXS: Ways and Means to Study Structural Flexibility of Biological Macromolecules

Thursday, November 17, 2011 - 10:30am

Dr. Alexander V. Shkumatov, Biological Small Angle Scattering Group, EMBL Hamburg

Small-angle X-ray scattering (SAXS) is universal low-resolution method to study native particles in solution and analyze structural changes in response to variations of external conditions. SAXS is providing high-precision information with respect to size and shape of particle systems. Moreover, one can study structure of partially or completely unfolded proteins, like tau protein involved in Alzheimer's disease. In comparison to other structure determination methods, like NMR or X-ray crystallography, SAXS allows one to overcome size and experiment time limitations. In my talk I will mention recent methodological developments for analysis of SAXS data, as well as present several biological examples.

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