BL12-1: A New Microfocus Beamline to Study the Most Challenging Biological Systems Commissioning Phase
BL12-1 will be a preeminent macromolecular crystallography capability for structural biology research in the US and has been designed for investigations of the most challenging macromolecular crystallography systems confronting scientists today, including cases where crystals can only be grown to a few microns in size. BL12-1 will be competitive with the performance of the best in class micro-beam instruments in the US (e.g., the native vertical focus of 5 µm and a collimated beam size of 1.5 µm2 will produce a flux density >6x that of SSRL BL12-2). BL12-1 will have improved performance at low energy and will be equipped with an Eiger 16M pixel array detector with readout speeds up to 133 Hz full detector and 750 Hz for regions of interest which will enable ultra-high-redundancy SAD experiments and routine serial crystallography experiments using liquid jets. BL12-1 will be an effective gateway for the Linac Coherent Light Source (LCLS), providing a platform for instrument R&D, prescreening and characterization of micro- to nano-crystalline samples prior to LCLS studies. BL12-1 is currently in the optics commissioning phase.