Speaker: Tsumoru Shintake, OIST
Program Description:
By blocking the central part of the objective lens in optical microscopy, we may improve resolution and contrast dramatically. This is a new type of telecentric optics based on central obscuration. This idea is a revival of old precession method in X-ray crystallography, which was developed by Martin J. Buerger at the beginning of the 1940's as a very clever alternative to collect Bragg diffractions without distorting the geometry of the reciprocal planes. In the EUV lithography, by introducing (precession method) rotating mirror and center obscured hollow mirror, we may go beyond 10 nm rule. In Cryo-EM, by precessing electron beam, we may directly observe molecule array in protein crystals, which provide powerful tool for protein analysis and drug discovery.
