Synchrotron Small Angle X-ray Scattering Studies Reveal the Role of
Neuronal Protein Tau in Microtubule Bundle Formation with Architectures
Mimicking those Found in Neurons –
Contacts: Peter Chung (University of Chicago) and Cyrus Safinya (University
of California, Santa Barbara)
Microtubules (MTs) are sub-cellular structures made of the protein tubulin.
They have important roles in moving organelles around the cell and in
chromosome segregation before cell division. MTs can exist in two states,
either a dynamic state of growing and shrinking MTs or a stable state. MTs can
also form complex bundles that can be found in neuronal axons. The neuronal
protein Tau helps facilitate this process and has been implicated in some
neurodegenerative disorders like Alzheimer’s disease. Yet Tau’s
exact role in MT formation and bundling is unclear: different experiments (both
in vivo and cell free) have shown Tau to mediate either attractive or
repulsive forces between MTs. Read more...
Beam Line Instrumentation Development
Instrument Finds New Earthly Purpose
Excerpt from February 23, 2017 Article in Symmetry by Amanda
TES array and cover shown with penny coin for scale.
–Dan Schmidt, NIST
Modern cosmology experiments—such as the BICEP instruments and the
Keck Array in Antarctica—rely on superconducting photon detectors to
capture signals from the early universe.
These detectors, called transition edge sensors, are kept at temperatures
near absolute zero, at only tenths of a Kelvin. At this temperature, the
“transition” between superconducting and normal states, the sensors
function like an extremely sensitive thermometer. They are able to detect heat
from cosmic microwave background radiation, the glow emitted after the Big
Bang, which is only slightly warmer at around 3 Kelvin.
NIST scientists design and build the thin, superconducting sensors and turn
them into pixelated arrays smaller than a penny. They construct an entire x-ray
spectrometer system around those arrays, including a cryocooler, a refrigerator
that can keep the detectors near absolute zero temperatures.
Over the past several years, these x-ray spectrometers built at the NIST
Boulder MicroFabrication Facility have been installed at BL10-1 at SSRL, the
NSLSII, and the APS to be used in a new capacity, that is for synchrotron
radiation research. Read more...
RapiData 2017 at SSRL – Data Collection and Structure
Solving: A Practical Course in Macromolecular X-ray Diffraction Measurement,
April 16-21, 2017, Menlo Park, CA
The announcement, agenda, registration and additional information are now
available at the RapiData 2017 website
canSAS-IX Meeting, June 5-7, 2017, San Francisco, CA
Please join us in San Francisco for canSAS-IX Meeting from June 5-7, 2017.
The meeting will be hosted jointly between the Advanced Light Source at
Lawrence Berkeley National Laboratory and Stanford Synchrotron Radiation
Lightsource at SLAC National Accelerator Laboratory. The collective action for
nomadic materials science small angle scatterers (canSAS) is an ongoing
activity to provide the small-angle scattering user community with shared tools
and information. For more information please visit both canSAS and the meeting
7th International Conferences on Hard X-ray Photoelectron
Spectroscopy, September 11-15, 2017, Berkeley, CA
The 7th International Conferences on Hard X-ray Photoelectron Spectroscopy
(HAXPES, HXPS, HX-PES,...) brings together researchers from a wide variety of
fields, from fundamental condensed matter and atomic and molecular physics to
more applied surface and interface studies of catalysis, energy and IT device-
and process- development, and environmental research. HAXPES is here defined as
involving photon energies in the multi-keV range above about 2 keV, but the
conference also encourages studies involving complementary photoemission
measurements at lower energies, as well as other x-ray-based techniques. The
use of HAXPES as a newly developed analytical tool, is expanding rapidly, both
making use of synchrotron radiation and laboratory sources. Register online or
contact the Co-Chairs for more information: Piero Pianetta (Stanford/SSRL),
Chuck Fadley (UC Davis/LBNL), and Zahid Hussain (LBNL). Conference website
SSRL/LCLS Users' Conference & Workshops, September 27-29,
2017, Menlo Park, CA – Workshop Topics due March 14
Planning has started for the next joint SSRL/LCLS Users' Conference.
Please mark your calendars to save these dates: September 27-29, 2017. We
would appreciate your suggestions or feedback about what worked well, who you
would like to hear from, or what you would like to see at the Users'
Proposals for half-day workshops are due by March 14: include a working
title, brief description of the science area or topics that could be discussed,
and potential organizers.
Please contact David
Bushnell (SSRL UEC), Christoph
Bostedt (LCLS UEC) or the Users
Office to share your input.
Call for User Publications, Theses, Awards, Patents and Invited
Once again we are preparing for a triennial review of SSRL by the DOE Office
of Basic Energy Sciences. Productivity in the area of user publications is one
metric covered by the review. We would like to express our thanks for the
many publications that you have reported to date and request your help with
compiling a complete listing of journal papers, theses, awards, patents,
conference proceedings papers and book chapters for this review. At this
time we are also asking for invited talks over the past three years covering
2014-2016 (include talk title, meeting name, date and location).
We will also send a request out under a separate cover and plan to include a
search and submittal form to help with the process. In the meantime you
can send publication updates via email directly to Lisa Dunn. More information and
publication lists are also available on our publications page
User Research Administration
SSRL Beam Time Request Deadline
- April 18, 2017 – Macromolecular Crystallography (June through
July beam time)
SSRL Proposal Deadlines
- April 1, 2017 – Macromolecular Crystallography
- June 1, 2017 – X-ray / VUV
Note: Rapid Access Requests for selected beam lines can be submitted at
any time. Submit proposals and beam time requests through the user portal.
The Stanford Synchrotron Radiation Lightsource (SSRL) is a third-generation
light source producing extremely bright x-rays for basic and applied
research. SSRL attracts and supports scientists from around the world who
use its state-of-the-art capabilities to make discoveries that benefit society.
SSRL, a U.S. DOE Office of Science national user facility, is a Directorate of
SLAC National Accelerator Laboratory, operated by Stanford University for the
U.S. Department of Energy Office of Science. The SSRL Structural
Molecular Biology Program is supported by the DOE Office of Biological and
Environmental Research, and by the National Institutes of Health, National
Institute of General Medical Sciences. For more information about SSRL science,
operations and schedules, visit http://www-ssrl.slac.stanford.edu.
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