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A High Resolution, Hard X-ray Bio-Imaging Facility at SSRL The TXM, developed at the 54 pole wiggler beam line 6-2 (BL6-2) at SSRL, is based on zone plate optics using absorption contrast over a wide energy range from 5-14 keV and Zernike phase contrast at 8 keV. The instrument offers complementary capabilities to many imaging tools that are widely deployed in biomedical research The high-resolution "virtual sectioning" capability of this instrument enables imaging at 40 nm resolution of any number of pre-selected regions within a visible light microscope specimen or even a cylindrical specimen.  Normal mouse tibia trabecular region in microCT at 10 µm resolution (left), followed by 20X objective differential interference contrast picture of a single thin trabecula, at ~ 0.75 µm resolution (center), followed by TXM mosaic composite with phase contrast at 8 keV, with 40 nm resolution (right). Each frame is 13.9 µm square. Background removal was improved using Adobe Photoshop  If you would like to read the full research paper please click on the PDF icon to download the research paper that explores the new TXM imaging technology at SSRL. |
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Advance the Understanding of Biological Systems
Overall, the instrument offers several unique and complementary capabilities that are expected to have a significant impact for biologists studying complex biological structures. These include:
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